DGKi regulates presynaptic release during mGluR-dependent LTD
نویسندگان
چکیده
Jinhee Yang, Jinsoo Seo, Ramya Nair, Seungnam Han, Seil Jang, Karam Kim, Kihoon Han, Sang Kyoo Paik, Jeonghoon Choi, Seunghoon Lee, Yong Chul Bae, Matthew K Topham, Stephen M Prescott, Jeong-Seop Rhee, Se-Young Choi* and Eunjoon Kim* Department of Biological Sciences, National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea, Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany, Department of Anatomy and Neurobiology, BK21, School of Dentistry, Kyungpook National University, Daegu, Korea and Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
منابع مشابه
DGKι regulates presynaptic release during mGluR-dependent LTD.
Diacylglycerol (DAG) is an important lipid second messenger. DAG signalling is terminated by conversion of DAG to phosphatidic acid (PA) by diacylglycerol kinases (DGKs). The neuronal synapse is a major site of DAG production and action; however, how DGKs are targeted to subcellular sites of DAG generation is largely unknown. We report here that postsynaptic density (PSD)-95 family proteins int...
متن کاملAltered Presynaptic Vesicle Release and Cycling during mGluR-Dependent LTD
The site of modification of synaptic transmission during long-term plasticity in the mammalian hippocampus remains controversial. Here we used a fluorescent marker of presynaptic activity, FM 1-43, to directly image presynaptic function during metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) at CA3-CA1 excitatory synapses in acute hippocampal slices. We found a signifi...
متن کاملLoss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function.
The autism spectrum disorder tuberous sclerosis complex (TSC) is caused by mutations in the Tsc1 or Tsc2 genes, whose protein products form a heterodimeric complex that negatively regulates mammalian target of rapamycin-dependent protein translation. Although several forms of synaptic plasticity, including metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), depend on p...
متن کاملPresynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.
To investigate the role of M1 muscarininc acetylcholine receptors (m1 receptors) in metabotropic glutamate receptor (mGluR)-mediated long-term depression (LTD), we produced mouse lines in which deletion of the m1 gene is restricted to the forebrain (FB-m1KO) or hippocampal CA3 pyramidal neurons (CA3-m1KO). Stimulation in FB-m1KO hippocampal slices resulted in excitatory postsynaptic potentials ...
متن کاملThe Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology.
In vertebrates, several groups of metabotropic glutamate receptors (mGluRs) are known to modulate synaptic properties. In contrast, the Drosophila genome encodes a single functional mGluR (DmGluRA), an ortholog of vertebrate group II mGluRs, greatly expediting the functional characterization of mGluR-mediated signaling in the nervous system. We show here that DmGluRA is expressed at the glutama...
متن کامل